Relative bioavailability of salbutamol to the lung following inhalation using metered dose inhalation methods and spacer devices.
نویسندگان
چکیده
منابع مشابه
Relative bioavailability of salbutamol to the lung following inhalation using metered dose inhalation methods and spacer devices.
BACKGROUND Inhalation aids do not require coordination between actuation of a metered dose inhaler (MDI) with inspiration and reduce oropharyngeal impaction. The delivery of salbutamol to the lung and systemic availability following inhalation with three commonly used spacers and an open mouth technique have been evaluated using a simple noninvasive technique based on urinary excretion 30 minut...
متن کاملLung bioavailability of generic and innovator salbutamol metered dose inhalers.
BACKGROUND The aim of this study was to determine whether significant differences exist in lung bioavailability between generic (Salamol, Salbulin) and innovator (Ventolin) formulations of inhaled salbutamol given by metered dose inhalers. METHODS Ten healthy volunteers of mean age 20.5 years with a forced expiratory volume in one second (FEV1) of 112.1% predicted were studied in a randomised...
متن کاملEffect of multiple actuations, delayed inhalation and antistatic treatment on the lung bioavailability of salbutamol via a spacer device.
BACKGROUND The aim of this study was to extend previous in vitro observations regarding the effects of multiple actuations of aerosols into spacer devices, delayed inhalation, and antistatic treatment of spacer devices on the amount of drug delivered for inhalation. An in vivo study of lung bioavailability of salbutamol from a large volume (Volumatic) spacer was conducted. METHODS Ten healthy...
متن کاملMetered dose inhalers and spacer devices.
Easy to carry, highly effective and extremely safe, allowing accurate, consistent dose delivery, metered dose inhalers are the inhalation devices doctors and patients choose most readily the world over. Clinical response, however, may be affected by the inhalation technique used and the precise formulation in the canisters. The purpose of this review is to consider metered dose inhalers, add on...
متن کاملSalbutamol inhalation and dental caries
Introduction Salbutamol (Ventolin) is a β2-sympathicomimetic drug, which was granted a marketing authorization in 1973. It is indicated for the treatment of reversible airway obstruction in bronchial asthma, chronic bronchitis and emphysema [1]. Both child and adult asthmatics use this inhalation medication, the difference lies in the dosage and vehicle of delivery. Dental caries as an ADR of s...
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ژورنال
عنوان ژورنال: Thorax
سال: 1994
ISSN: 0040-6376
DOI: 10.1136/thx.49.6.549